Living with Ankylosing Spondylitis: The Blog

A blog for and by people living with AS

Axial Spondyloarthritis Seen in 1 in 5 Young Adults With Chronic Back Pain

A good summary of the findings of the study, the story states, “Approximately 20% of cases of chronic low back pain in younger adults seen in primary care settings might be caused by spondyloarthritis…”

“The results suggest that spondyloarthritis is underdiagnosed as a cause of chronic back pain in the general population.”

via Press – News – 463 – FOLLOW-UP: Axial Spondyloarthritis Seen in 1 in 5 Young Adults With Chronic Back Pain.

Efficacy in current practice of switching between anti-tumour necrosis factor-a agents in spondyloarthropathies

The Tumor-Necrosis-Factor alpha (TNF-a) blockers are biologic medications that have shown great promise in treating ankylosing spondylitis. They have been shown to be highly effective in treating not only the arthritis of the joints but the spinal arthritis associated with ankylosing spondylitis and related diseases.

This study looked at the effectiveness of switching between TNF-a medications to see if one would work when another had not.

The authors conclude that, “In the event of failure or intolerance to anti-TNF-a in the treatment of [spondyloarthropathies], performing a first or second switch produces a satisfactory therapeutic response.

via Press – News – 462 – Efficacy in current practice of switching between anti-tumour necrosis factor-a agents in spondyloarthropathies.

Diet, disease activity, and gastrointestinal symptoms in patients with ankylosing spondylitis

From the study’s abstract, “The aims of this study were to investigate, firstly, the relationship between diet and disease activity and, secondly, the presence of gastrointestinal symptoms and their relationship to diet among patients with ankylosing spondylitis (AS).”

The study’s authors concluded that, “in a group of Swedish AS patients, no correlation between diet and disease activity could be detected. There were, however, correlations between diet and gastrointestinal pain. Gastrointestinal problems were also found to be prevalent in AS, independent of NSAID usage.”

via Press – News – 460 – Diet, disease activity, and gastrointestinal symptoms in patients with ankylosing spondylitis.

Classification criteria for psoriatic arthritis and ankylosing spondylitis/axial spondyloarthritis

Classification criteria for psoriatic arthritis and ankylosing spondylitis/axial spondyloarthritis

Posted on: 12/6/2010

Classification criteria for spondyloarthritis has been constantly evolving as new research presents itself and the group of diseases is better understoood.An article in Clinical Rheumatology states that, “new criteria for psoriatic arthritis have been developed recently.”The authors state, “These criteria were validated in the Assessment of Spondyloarthritis International Society ASAS study on new classification criteria for axial SpA, a large international prospective study. In this new criteria, sacroiliitis showing up on MRI has been given as much weight as sacroiliitis on radiographs, thereby also identifying patients with early axial SpA.

via Press – News – 459 – Classification criteria for psoriatic arthritis and ankylosing spondylitis/axial spondyloarthritis.

Low bone mineral density is related to male gender and decreased functional capacity in early spondylarthropathies

Low bone mineral density is related to male gender and decreased functional capacity in early spondylarthropathies

Posted on: 9/7/2010

An article in Clinical Rheumatology examines the prevalence and risk factors of low bone mineral density (BMD) in early stages of spondylarthropathies (SpA).

The authors found that, “In total, 9% of the early SpA patients had osteoporosis, 38% osteopenia, and 53% normal BMD.” And that, “In early SpA patients, a high frequency (47%) of low BMD in femur as well as in lumbar spine was found.”

Overall, the researches conclude that, “Low BMD was associated with male gender and decreased functional capacity. These findings emphasize the need for more alertness for osteoporosis and osteopenia in spondylarthropathy patients at an early stage of the disease.”

To read the abstract, click here.

via Press – News – 439 – Low bone mineral density is related to male gender and decreased functional capacity in early spondylarthropathies.

Newsroom – UTHealth scientists zeroing in on genes tied to two immune disorders

UTHealth scientists zeroing in on genes tied to two immune disorders

TARGETED RESEQUENCING OF IMMUNE-ASSOCIATED GENES – UTHealth researcher Xiaodong Zhou, M.D., will perform a study of the human leukocyte antigen (HLA) genomics of ankylosing spondylitis and scleroderma.

HOUSTON – (Sept. 7, 2010) – A new study designed to test suspected links between genes and two immune disorders could open the door to better ways to diagnose and treat the conditions that affect a combined total of approximately 2.5 million people in the United States, report scientists at The University of Texas Health Science Center at Houston (UTHealth).

The genes are thought to be associated with ankylosing spondylitis, a form of arthritis that attacks the spine, and systemic sclerosis (scleroderma), a chronic, often progressive, disease of connective tissue. As many as 2.4 million people in the United States may be affected by ankylosing spondylitis and its related diseases. Systemic sclerosis impacts about 100,000 people in the United States.

The researchers plan to conduct an exhaustive analysis of these genes and others using a research technique called targeted resequencing. The study will involve more than 6,000 patients with ankylosing spondylitis or scleroderma from the United States, China and Spain and it will focus on an area of the genome linked to immunity issues called the major histocompatibility complex. The study will also include about 3,000 people without the conditions.

“This is the most complicated region of the human genome,” said Xiaodong Zhou, M.D., a principal investigator and associate professor of internal medicine at the UTHealth Medical School. “The region contains genes linked to all types of immune diseases. In many instances, we don’t know precisely where the linkage comes from. We want to find out if these are true associations.”

KEEP READING HERE:   Newsroom – UTHealth scientists zeroing in on genes tied to two immune disorders.

Press – News – 443 – Determinants of Early Radiographic Progression in Ankylosing Spondylitis

Determinants of Early Radiographic Progression in Ankylosing Spondylitis

Posted on: 9/20/2010

A study in The Journal of Rheumatology investigates, “the demographic and clinical characteristics associated with early, extensive radiographic changes in ankylosing spondylitis (AS).”

The authors found that early axial ankylosis (EAA) “was more frequent in men with AS than in women. Absence of peripheral arthritis, HLA-B27 positivity, and uveitis were associated with multiple syndesmophytes or fusion of multiple vertebrae of the lumbar vertebrae.”

via Press – News – 443 – Determinants of Early Radiographic Progression in Ankylosing Spondylitis.

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